Drug Interactions
Darolutamide Interactions
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Tramadol-acetaminophen
No clinically significant drug interactions identified.
Trazodone
No clinically significant drug interactions identified.
Valsartan
Caution - increased level of valsartan due to OAT inhibtion. Monitor for signs of toxicity (ie. SCr, K+). If initiating therapy, titrate slowly. If already established on therapy, may require dose reduction. Consider choosing an alternative agent.
Venlafaxine
No clinically significant drug interactions identified.
Verapamil
No clinically significant drug interactions identified.
Warfarin
Caution - monitor INR more closely after initiation of darolutamide therapy or dose changes. Potential increased toxicity of warfarin (bleeding) due to enzyme inhibition. Titrate warfarin dose to target INR.
Zopiclone
No clinically significant drug interactions identified.
