Drug Interactions

Caution - decreased level of tramadol due to 3A4 induction. Monitor for efficacy - higher doses than anticipated may be required. Consider choosing an alternative agent.

Avoid combination - decreased level of trazodone due to 3A4 induction. Choose an alternative agent.

No clinically significant drug interactions identified.

No clinically significant drug interactions identified.

Avoid combination - decreased level of verapamil due to 3A4 induction. Choose an alternative agent.

Caution - decreased level of warfarin due to 2C9/3A4/2C19 induction. Monitor INR more closely after initiation of enzalutamide therapy or dose changes. Titrate warfarin dose to target INR.

Caution - decreased level of zopiclone due to 3A4 induction. Monitor for efficacy - higher doses than anticipated may be required. Consider choosing an alternative agent.